Prophylactic CNS therapy in childhood acute leukemia: Review of methods used

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By use of prophylactic CNS therapy in children with ALL, the incidence of central nervous system relapse was dramatically reduced and the length of the initial bone marrow remission was significantly prolonged. Following this important discovery, many additional regimens for prophylactic CNS therapy were tried in an effort to improve upon the early results obtained at St. Jude Children's Research Hospital. Ten additional CNS therapy regimens were found which gave results equivalent to, but not better than, the St. Jude results.

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