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The neural integration of heat dissipation is wholly dependent upon the anatomical integrity of the subthalamic and cephalic midbrain level of the brainstem. Except for a possible permissive function, heat dissipation is quite independent of the hypothalamus. Presumptively, it is concluded that tissues within or near the anterior hypothalamus play a permissive role concerned with determining the core temperature level (39°C.) at which the heat-dissipation outflow is activated. Afferent impingements originating from non-thermal peripheral receptors exert a modulating influence on the central integration of responses to both heat and cold. The neural integration of resistance-to-hypothermia is wholly dependent upon the anatomical integrity of the hypothalamic grey and is completely independent of tissues lying cephalad to the hypothalamus. The resistance-to-hypothermia outflow is more susceptible to impairment than is the heat-dissipation outflow following trauma to the cephalic portion of the diencephalon.