Effects of Aging on Respiratory Load Compensation and Dyspnea Sensation

    loading  Checking for direct PDF access through Ovid


To clarify effects of aging on the load compensation response and the sensation of dyspnea, we examined 28 healthy male volunteers for ventilatory and P0.1 responses to hyperoxic progressive hypercapnia with and without inspiratory flow-resistive loading (17 cm H2O/L/s) while the intensity of dyspnea was simultaneously assessed by visual analogue scaling every 15 s. Of the 28 subjects, 14 were 61 to 79 yr of age and were classified as the older group; the others, 19 to 48 yr of age, were classified as the control group. Neither ΔV̇e/ΔPetCO2 nor ΔP0.1/ΔPetCO2 was different between the two groups without loading. In the control group, the ΔP0.1/ΔPetCO2 increased with loading (p < 0.01) without a change in the ΔV̇e/ΔPetCO2. In the older group, the ΔP0.1/ΔPetCO2 did not change with loading so that the ΔV̇e/ΔPetCO2 decreased with loading (p < 0.01). In the 28 subjects as a whole, the percent change in ΔP0.1/ΔPetCO2 with loading was inversely correlated with age (r = −0.53, p < 0.01). At PetCO2 levels of 45, 50, and 55 mm Hg, irrespective of loading, the dyspnea intensity was greater in the older group than in the control group, whereas the P0.1 expressed as its ratio to the predicted maximal inspiratory mouth pressure was not different between the two groups. We conclude that aging attenuates the compensatory response to inspiratory flow-resistive loading and it increases the intensity of dyspnea for a given level of PetCO2.

Related Topics

    loading  Loading Related Articles