Müllerian Adenosarcoma of the Uterus and Its Diagnostic Mimics

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Abstract

Müllerian adenosarcomas of the uterus are rare biphasic neoplasms in which a benign epithelial component and a malignant mesenchymal component are admixed in a specifically patterned configuration. The morphologic spectrum of Müllerian adenosarcomas is wide, and lesions at the lower end of the spectrum of abnormalities may display significant morphologic overlap with benign entities, whereas lesions on the opposite end of the spectrum may overlap with malignant entities that are managed differently from Müllerian adenosarcoma. In this article, the authors review the current state of knowledge on the pathologic features of this enigmatic entity, with an emphasis on differential diagnosis.

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