Small Round Blue Cell Tumors: Pitfalls of Overlapping Clinical, Histological, and Molecular Characteristics

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Accurately diagnosing poorly differentiated “small round blue cell tumors” presents special challenges due to the overlapping histological, immunohistochemical, and molecular features of these tumors. Establishing the correct diagnosis while minimizing time and cost requires selection and appropriate interpretation of immunohistochemical and molecular tests to confirm the diagnosis. We present a case of a small round blue cell tumor and discuss the diagnostic pitfalls, with particular attention to overlapping immunohistochemical features of tumors in the differential diagnosis.

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