Light-chain deposition disease (LCDD) is an unusual multisystem disorder, rarely involving the lung. Pulmonary LCDD can manifest in nodular and cystic forms. While the nodular form may be asymptomatic, the cystic variety usually leads to severe respiratory failure necessitating lung transplantation. Our report consists of 2 cases—one of each type of pulmonary LCDD. We present their clinical/radiological, histological, and ultrastructural features, review the literature, and emphasize the relationship and differentiation of LCDD from immunoglobulin light-chain amyloidosis.