Pathologic Staging of Bone and Soft Tissue Tumors: What Is New in the Eighth Edition of the American Joint Committee on Cancer Staging Manual?

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Abstract

The recently published eighth edition of the AJCC Cancer Staging Manual addresses and incorporates a substantial number of advances in our understanding of bone and soft tissue sarcomas. A greater emphasis has been placed on the anatomic site of origin resulting in new staging systems. In addition, modifications to the existing AJCC prognostic stage groups and implementation of new prognostic stage groups for certain anatomic sites and tumor types were made. Minor changes in the biologic grading of bone sarcomas were also included. For retroperitoneal soft tissue sarcomas, a nomogram providing additional prognostic information has been endorsed by the AJCC Precision Medicine Core and is included as a risk assessment model. Pathologists play a central role in tumor staging and therefore should become familiar with these changes.

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