An Orchestrated Dance Between Differing Regulatory T Cell Phenotypes in Allograft Tolerance

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While the field has focused largely on Foxp3+ Tregs as mediators of regulatory allograft tolerance, a new study provides evidence that a ‘division of labor’ can occur between Tregs and IL-10-producing Tr1 cells in which each regulatory cell type can be required during differing phases of the tolerogenic response. See article by Gagliani et al on page 1963.

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