RIVASTIGMINE IN WERNICKE-KORSAKOFF'S SYNDROME: FIVE PATIENTS WITH RIVASTIGMINE SHOWED NO MORE IMPROVEMENT THAN FIVE PATIENTS WITHOUT RIVASTIGMINE

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Abstract

Aims

To evaluate whether rivastigmine, an achetylcholinesterase inhibitor (AChEl), may be effective in restoring memory in Wernicke-Korsakoff's syndrome (WKS).

Methods

Five patients treated with rivastigmine for a period of 6 months were compared with five matched control patients, who received 6 months' conventional treatment, but without rivastigmine. Memory tests were administered at baseline and after 6 months.

Results

Slight improvements were observed in both rivastigmine and control patients, but no significant differences in improvements were found between the study groups.

Conclusion

Treatment with rivastigmine may not be effective in restoring memory in WKS patients.

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