Predictors of reduced health-related quality of life in adults with coeliac disease

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Abstract

Background

Data available on predictors of reduced health-related quality of life in coeliac disease are not consistent.

Aim

To test predictors of reduced health-related quality of life, described in the literature, by a multivariate approach.

Methods

1000 adult coeliacs of the German Coeliac Society completed a medical and a sociodemographic questionnaire, the Short-Form Health Survey (SF-36), the Coeliac Disease Questionnaire and the Hospital Anxiety and Depression Scale within a postal survey. Predictors of reduced health-related quality of life were tested for by logistic regression analysis.

Results

Physical comorbidities (β = −0.41; OR = 0.66, P < 0.001) and mental disorder (β = 0.88; OR = 2.4, P = 0.03) were associated with a reduced physical summary score of the SF-36. Mental disorder (β = 2.5; OR = 11.9, P < 0.001), physical comorbidities (β = −0.26; OR = 0.77, P = 0.004) and younger age at diagnosis (β = −0.10; OR = 0.91, P = 0.05) predicted a reduced mental summary score of the SF-36. Mental disorder (β = 0.90; OR = 2.5, P = 0.03), non-compliance with gluten-free diet (β = 0.44; OR = 1.6, P = 0.009), active medical comorbidities (β = −0.28; OR = 0.76, P = 0.007) and dissatisfaction with doctor–patient communication (β = 0.55; OR = 1.7, P = 0.03) were associated with reduced Coeliac Disease Questionnaire scores.

Conclusions

Reduced health-related quality of life in coeliac disease is associated not only with physical and mental comorbidities, but also with non-compliance with gluten-free diet and dissatisfaction with doctor–patient communication.

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