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Through a small but exquisite study, the authors of this investigatory intervention trial provide a plausible subcellular explanation for massage therapy’s purported benefits on injured muscle using muscle biopsy and subsequent gene profiling. The application of similar study techniques might be expected in future studies of other CAM therapies directed against pain.Crane JD, et al. Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage. Sci Trans Med 2012;119:1.