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To provide advanced practice nurses (APNs) with information necessary to participate in pandemic influenza planning and response. Key epidemiological terms and pandemic alert designations are reviewed. Influenza surveillance activities at the local, state, and national levels are summarized. Responsibilities of the APN are discussed, and resources are provided.Review of the published literature, epidemiology text books, U.S. Department of Health and Human Services (USDHHS) Pandemic Influenza Plan, state pandemic influenza plans, U.S. Centers for Disease Control and Prevention, World Health Organization, and USDHHS Internet resources.Recent public health emergencies have brought to light the need for APNs to become educated regarding emergency planning and response. APNs should be familiar with terminology, current activities, and potential responsibilities.Resources presented in this article will help prepare APNs to participate in planning and response activities for pandemic influenza.