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A small college health center discovered that students perceived obtaining prescribed medication was a barrier to adherence to short-term antibiotic therapy. To address this specific barrier, an in-house dispensary was developed and modified over the past several years to meet the needs of students. Partnering with a local pharmacy has made the process of obtaining prescriptions easier for the students.Data were extracted from the electronic health records at Student Health Services for the academic year 2014–2015. A total of 910 prescriptions were filled in-house during that time, compared to 102 prescriptions written for purchase elsewhere.Students are utilizing the in-house dispensary more often than taking a prescription to a pharmacy and generally regard the service as convenient. Despite challenges in changing drug prices and other factors that influence medication adherence, dispensing a small number of drugs in the clinic has been feasible and well received.Nurse practitioners must be aware of specific perceived barriers for their practice population and develop interventions to overcome them. The evaluation of such interventions is imperative for modifications and sustainability.