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Amantadine, an anti-influenza agent, is commonly used in the treatment of parkinsonism. It also has serotonergic activity. Amantadine can induce toxicity in patient with renal dysfunction because it is excreted mainly in the urine. We report a rare case of amantadine-induced serotonin syndrome in a 78-year-old man with Parkinson's disease and renal failure who developed confusion, hallucination, agitation, myoclonus, fever, diarrhea, and hypertension after amantadine use.