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Spontaneous pneumomediastinum (SPM) is an uncommon disease arising most frequently with young adults, and SPM after air travel has never been reported. We show herein a case of SPM after air travel. The exact mechanism of SPM in our patient is unknown, but we suppose that her thin and tall build (body mass index, 16.9 kg/m2) and medical history of bronchial asthma in childhood have some relationship to the development of SPM. In addition to pneumothorax and pulmonary embolism, SPM should be considered in patients with chest pain during and after air travel, especially in young and thin subjects with a history of current or previous bronchial asthma.