Glycemia and Levels of Cerebrospinal Fluid Amyloid and Tau in Patients Attending a Memory Clinic

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Abstract

OBJECTIVES:

To determine the association between markers of glycemia and cerebrospinal fluid (CSF) amyloid β 1–42 (Aβ42) and tau levels in patients attending a memory clinic.

DESIGN:

Cross-sectional study.

SETTING:

Memory clinic.

PARTICIPANTS:

Two hundred forty-five consecutive patients attending a memory clinic. Clinical diagnoses were subjective cognitive complaints (n=91), mild cognitive impairment (n=62), Alzheimer's disease (n=58), and other dementia (n=34). Twenty-one patients had diabetes mellitus.

MEASUREMENTS:

Glycosylated hemoglobin (HbA1c); fasting blood glucose levels; and CSF levels of Aβ42, total tau, and p-tau 181.

RESULTS:

In regression analyses across the whole study sample adjusted for age, sex, and diagnostic group, there was no relationship between HbA1c or fasting glucose and CSF tau, p-tau 182, or Aβ42 levels. Stratification for diabetes mellitus did not change the results.

CONCLUSION:

These observations do not support the hypothesis that the association between dysglycemia and impaired cognitive functioning is mediated through aberrant amyloid or tau metabolism.

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