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Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage.A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)2.5 were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM2.5, adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications.The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM2.5.Our results indicate no association between occupational PM2.5 exposure and this marker of global oxidative stress. Am. J. Ind. Med. 55:953–960, 2012. © 2012 Wiley Periodicals, Inc.