Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics: Optical coherence tomography study

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Abstract

Background

Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear.

Methods

We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments.

Results

Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8% vs MS 3.6% vs DS 21%: PS vs MS, P < .001: MS vs DS, P < .001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15% vs MS 5.4% vs DS 13.8%: PS vs MS, P = .001: MS vs DS, P = .001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6% vs 20.5%, P < .001). The incidence of NA was higher, when adjacent plaque was lipid (43.2% with lipid plaque vs 12.2% without lipid plaque, P < .001).

Conclusion

Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.

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