Suppression of mammary tumors by oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice

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Abstract

Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed not only de novo but also salvage pathways for pyrimidine nucleotide synthesis, and reduced mammary tumorigenesis and tumor growth in SHN virgin mice, which have a high potential for the incidence of mammary tumors.

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