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Abdominal compartment syndrome in the surgical neonate is a low-frequency, high-risk occurrence that if overlooked is often accompanied with long-term sequelae and sometimes death. The importance of early detection of signs and symptoms through expert nursing assessment cannot be overstated.To review the components of nursing assessment as it applies to detection of abdominal compartment syndrome in the surgical neonate and its relationship to the pathophysiology.Detailed search of the nursing and medical literature.The purpose of this article is to describe the onset of abdominal compartment syndrome in the neonate. Early detection of this low-frequency, high-risk occurrence hinges on expert nursing assessment. Complications of abdominal compartment syndrome in the neonate involve bowel perforation, short bowel syndrome, and sometimes death. Components of this expert nursing assessment and its relationship to the pathophysiology of compartment syndrome are presented.