The Effect of Ketamine on Regional Cerebral Blood Flow in Man

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Abstract

Total (CBF) and regional (rCBF) hemispheric cerebral blood flows were measured by the intra-arterial 133Xe method in five neurologic patients before and 2 to 4 minutes after intravenous injection of ketamine. While the responses of CBF were variable, marked increases in rCBF were observed in the frontotemporal regions in four of four and in the parieto-occipital region in three of 5 patients. It is concluded that ketamine is probably not a direct cerebrovasodilator, but that it may affect rCBF secondary to drug-induced changes in regional neuronal activity.

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