Effects of Lidocaine and Etidocaine on the Axoplasmic Transport of Catecholaminesynthesizing Enzymes

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Abstract

The effecs of lidocaine (0.5–1 per cent) and etidocaine (2 per cent) on rapid axoplasmic transport of calecholamine-synthesizing enzymes (tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine-β-hydroxylase) were studied vivo in guinea pigs. Sciatle nerves were ligated and accumulation of enzymes proximal to ligation gave a measure of the rate of transport. Exposure of the sciatic nerve to either local anesthetic produced analgesia but did not inhibit axoplasmic transport of these enzymes.

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