Pregnancy Decreases the Requirement for Inhaled Anesthetic Agents

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The effects of pregnancy on requirements for inhalation anesthetic agents were evaluated. The minimum alveolar concentrations (MAC) of halothane, methoxyflurane, and isoflurane needed to prevent movement in response to a standard stimulus were determined in six pregnant and six nonpregnant ewes. Pregnancy was associated with significant reductions in MAC of 32 per cent for methoxyflurane, 25 per cent for halothane, and 40 per cent for isoflurane.

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