Atrioventricular Conduction in Dogs during Anesthesia with Isoflurane

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The effects of 1.25, 2.0, and 2.5 MAC isoflurane on atrio-ventricular conduction were studied by His-bundle electrocardiography during atrial pacing in ten dogs. No effect upon atrioventricular conduction as evidenced by changes in A—H interval (the time of conduction from low right atrium to His-bundle, representing primary AV nodal conduction) was found at these concentrations. Atrial pacing to 200 beats/min did not influence the A—H interval at the three anesthetic concentrations. The stability of cardiac rhythm observed clinically with isoflurane may be related to this lack of effect upon the AV node.

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