Inhibition by Ether of Glucose-stimulated Insulin Secretion in Isolated Pieces of Rat Pancreas

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Addition of glucose (16.7 mM) to isolated pieces of rat pancreas increased insulin secretion 5.4-fold over basal secretion rates. Ether at 1, 1.5 and 2 MAC inhibited this insulinogenic effect of glucose in a dose-related manner by 5, 18 (P < 0.01) and 29 (P < 0.01) per cent, respectively.

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