Bilirubin Levels and Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction

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Abstract

We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of thrombus burden in patients with acute myocardial infarction. Patients (n = 229; male 72.9%; mean age 63 ± 13.4 years) who were admitted with ST-segment elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Patients with high thrombus burden had higher total bilirubin levels (14.4 [4.3–22.9] vs 7.7 [2.4–20.3] μmol/L, P ≤ .001), (0.84 [0.25–1.34] vs 0.45 [0.14–1.19] mg/dL P ≤ .001) and direct bilirubin levels (3.1 [2.1–8.4] vs 1.7 [0.5–6.5] μmol/L, P ≤ .001), (0.18 [0.03–0.49] vs 0.10 [0.03–0.38] mg/dL, P ≤ .001). At multivariate analysis, total bilirubin (odds ratio: 1.05, 95% confidence interval: 1.03–1.08, P ≤ .001) was the independent predictor of high thrombus burden. In conclusion, total bilirubin level is independently associated with high thrombus burden in patients with STEMI.

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