A New ATS Committee
Clinical Year in Review III
Introduction
Pathogenesis of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease Outcome Measurements
Combination Therapy for Chronic Obstructive Pulmonary Disease
Pharmacologic Principles for Combination Therapy
Synopsis of Discussions in Session 1
Molecular Mechanisms of β2-Adrenergic Receptor Function and Regulation
Cholinergic Pathways in the Lungs and Anticholinergic Therapy for Chronic Obstructive Pulmonary Disease
β2-Agonist and Anticholinergic Drugs in the Treatment of Lung Disease
Synopsis of Discussions in Session 2
Glucocorticoid Pathways in Chronic Obstructive Pulmonary Disease Therapy
Corticosteroids
Phosphodiesterase-4
Theophylline in Chronic Obstructive Pulmonary Disease
Synopsis of Discussions in Session 3
Innate Immune Responses and Chronic Obstructive Pulmonary Disease
The Role of Airway Smooth Muscle in the Pathogenesis of Airway Wall Remodeling in Chronic Obstructive Pulmonary Disease
The Role of Vagal Afferent Nerves in Chronic Obstructive Pulmonary Disease
Mechanisms and Experimental Models of Chronic Obstructive Pulmonary Disease Exacerbations
Systemic Effects of Chronic Obstructive Pulmonary Disease
Synopsis of Discussions in Session 4
Proteinases and Oxidants as Targets in the Treatment of Chronic Obstructive Pulmonary Disease
Inflammation-activated Protein Kinases as Targets for Drug Development
Challenges and Opportunities for Combination Therapy in Chronic Obstructive Pulmonary Disease
Synopsis of Discussions in Session 5