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Introduction
The Epidemiology and Economics of Chronic Obstructive Pulmonary Disease
Assessment Tools for Chronic Obstructive Pulmonary Disease
The Immunopathogenesis of Chronic Obstructive Pulmonary Disease
Systemic Effects of Chronic Obstructive Pulmonary Disease
Pharmacologic Interventions in Chronic Obstructive Pulmonary Disease
Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease
Pharmacologic Therapy
The Nonpharmacologic Treatment of Chronic Obstructive Pulmonary Disease
Exacerbations of Chronic Obstructive Pulmonary Disease
Selection of Controls in Clinical Trials
Placebo versus Best-Available-Therapy Control Group in Clinical Trials for Pharmacologic Therapies
Sham Procedure versus Usual Care as the Control in Clinical Trials of Devices
Usual Care as the Control Group in Clinical Trials of Nonpharmacologic Interventions