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The impact of an acute fever on semen variables is unclear. This paper reports negative effects and recovery of the sperm quality in a man who had an acute fever of 38°-39°C, due to a throat infection. The study evaluated the sperm quality in semen specimens collected, as follows: 1) one month before the fever; 2) 1-day after the fever; 3) 20 days after antimicrobial therapy. The first and third specimens were quite similar for all semen parameters. However, the second specimen showed unexpected results: not only a decrease in the sperm count, but also an increase of small-head sperm. This study aims to discuss this finding's implications for clinical and laboratory practice.