Annals of Clinical & Laboratory Science. 48(3):333–337, MAY-JUNE 2018

PMID: 29970437

Issn Print: 0091-7370

Publication Date: May-June 2018


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Associations between Single Nucleotide Polymorphisms in the Mitochondrial DNA D-Loop Region and Outcome of Gastroenteropancreatic Neuroendocrine Neoplasm

Li-Mian Er;Yong Li;Li Er;MingLi Wu;Xiu-li Zheng;Zhan-jun Guo;Hu-Fang Yuan;

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Abstract

Abstract.Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with cancer risk and disease outcome. We evaluated the predictive value of these SNPs for GEP-NEN outcome. Three SNP sites of nucleotides16257C/A, 150C/T and 151C/Tdel were identified for statistically significant prediction of postoperative survival in GEPNEN by univariate analysis with log-rank test. In addition, the minor haplotype of nucleotides 16257A in the hypervariable segment 1(HV1) region of the D-loop was identified for their association with lower survival rate of GEP-NEN (relative risk, 3.390; 95% CI, 1.071˜10.729; p=0.038) by multivariate analysis with COX hazards model. The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patient subgroups with a high risk of GEP-NEN outcome.

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