The various manifestations of malarial infection are common knowledge, but specific sensitivity to the protein of the malarial parasite is almost a medical curiosity. References to such a condition in the available literature are very few, and detailed case reports almost non-existent. The relationship between urticaria and malarial infection has been infrequently observed over the past 25 years, but as late as 1939 the possibility of urticaria existing coincidentally with and not related to malarial infection was under discussion. In 1928 Thonnard-Neumann described cases in Haiti in which treatment of malaria cured coexistent asthma. More recently urticaria as a result.