A randomized phase II trial comparing every 3-weeks carboplatin/paclitaxel with every 3-weeks carboplatin and weekly paclitaxel in advanced non-small cell lung cancer


    loading  Checking for direct PDF access through Ovid

Abstract

BackgroundThe optimal schedule of taxane administration has been an area of active interest in several recent clinical trials.MethodsTo address a pure schedule question, we randomized 161 patients with advanced stage IIIB or IV non-small-cell lung cancer (NSCLC) to either paclitaxel 225 mg/m2 every 3 weeks × 4 cycles or 75 mg/m2/week × 12 (cumulative dose on each arm=900 mg/m2). Both arms received concurrent carboplatin AUC 6 every 3 weeks × 4 cycles.ResultsThe two arms were well-balanced in terms of known prognostic factors. The overall response rate and survival outcomes were similar on the two arms. There was significantly more grade 3/4 thrombocytopenia and grade 2–4 anemia on the weekly arm but less severe myalgias/arthralgias and alopecia. No difference in the rates of peripheral neuropathy was observed; however, patients on the every 3 weeks arm reported significantly more taxane therapy-related side-effects on the functional assessment of cancer therapy taxane subscale.ConclusionsThis randomized trial exploring schedule-related issues with carboplatin/paclitaxel confirms the versatility of this regimen.

    loading  Loading Related Articles