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The optimal schedule of taxane administration has been an area of active interest in several recent clinical trials.To address a pure schedule question, we randomized 161 patients with advanced stage IIIB or IV non-small-cell lung cancer (NSCLC) to either paclitaxel 225 mg/m2 every 3 weeks × 4 cycles or 75 mg/m2/week × 12 (cumulative dose on each arm=900 mg/m2). Both arms received concurrent carboplatin AUC 6 every 3 weeks × 4 cycles.The two arms were well-balanced in terms of known prognostic factors. The overall response rate and survival outcomes were similar on the two arms. There was significantly more grade 3/4 thrombocytopenia and grade 2–4 anemia on the weekly arm but less severe myalgias/arthralgias and alopecia. No difference in the rates of peripheral neuropathy was observed; however, patients on the every 3 weeks arm reported significantly more taxane therapy-related side-effects on the functional assessment of cancer therapy taxane subscale.This randomized trial exploring schedule-related issues with carboplatin/paclitaxel confirms the versatility of this regimen.