Correlation between tumor response to first-line chemotherapy and prognosis in advanced gastric cancer patients


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Abstract

BackgroundIn advanced gastric cancer, the relationship between tumor response and prognosis is far from clear.MethodsWe performed a pooled analysis on published data from 4593 patients in 25 randomized trials of first-line chemotherapy for advanced gastric cancer. A weighed analysis was used to investigate the correlation between objective response rate (RR) and time to progression (TTP) and overall survival time (OS).ResultsA moderate correlation was found between RR and TTP and OS (r=0.49 and r=0.45, respectively) in all 25 trials. In treatment arms without new drugs including irinotecan, taxanes, or oxaliplatin, RR also was associated with TTP and OS (r=0.56 and r=0.47, respectively). However, no association between RR and OS was found, whereas there was a moderate correlation between RR and TTP (r=0.41) in treatment arms using new drugs.ConclusionsOur results indicated that response to treatment was related to TTP and OS. The potential role of objective response as a surrogate in chemotherapy trials of advanced gastric cancer warrants further investigation, especially with regard to treatment with new drugs.

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