PPP1R13L VARIANT AS A PROGNOSTIC FACTOR IN PATIENTS WITH RECTAL CANCER

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Abstract

Background

Genetic variants related with apoptosis and DNA repair pathways may play a meaningful role in cancer progression as well as carcinogenesis. Among them, PPP1R13L and ERCC1 polymorphisms was found to synergistically affect these pathways. The aim of this study was to investigate the association between these genetic variants and prognosis of colorectal cancer (CRC) operated curatively.

Methods

A total of 349 CRC patients underwent curative surgery between March 2003 and August 2006 were consecutively enrolled. DNA was extracted from fresh frozen normal tissue and each polymorphism (PPP1R13L rs1005165 and rs967591; ERCC1 rs11615 and rs735482) was genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP).

Results

No statistical significance between these four variants and survival in a multivariate analysis for all CRC patients. However, the CC genotype of the PPP1R13L rs1005165 was significantly associated with worse survival in 164 patients with rectal cancer (HR = 2.10 and P = 0.037 for RFS; HR = 2.27 and P = 0.039 for DSS, respectively) as a recessive model of the C allele in a multivariate analysis. Meanwhile, no statistical differences in clinicopathologic characteristics were observed according to the rs1005165 genotype in rectal cancer patients.

Conclusions

Our results suggest that PPP1R13L variant is possible prognostic marker in Korean patients with rectal cancer.

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