Tramadol is a weak agonist actions at the μ-opioid receptor, and acting on neurotransmission of SNRI. Fentanyl is a potent synthetic narcotic analgesic with a rapid onset and short duration of action. It is a strong agonist at μ-opioid receptors. Both tramadol and fentanyl patches are used for the carcinomatous pain in clinical.Method
Effecacy and the safety when switching from the tramadol to fentanyl sticking medcine in the third where the conversion chart based on 500:1 compared with general conversion is used in foreign countries are examined prospectively. All patients were required to provide written informed consent.Results
This study included 14 patients (12 men and 2 women), including 12 with adenocarcinoma, 1 with squamous cell carcinoma, 1 with mesothelioma. We examined control of pain, nausea, vomiting, constipation, sleepiness, and PS at the time of registration, a fentanyl patch change from tramadol, a first fentanyl patch change, a second fentanyl patch change, and a fourth fentanyl patch change. Furthermore, we examined degree of satisfaction about this trial and the change from tramadol to fentanyl patch, and the wish of whether to like to continue a fentanyl patch.Conclusion
We collecte 15 patients of target in this study and report the details of a result.