IMPACT OF DONOR SOURCE ON ALLOGENEIC STEM CELL TRANSPLANTATION FOR PHILADELPHIA CHROMOSOME-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA

    loading  Checking for direct PDF access through Ovid

Abstract

Background

Although allogeneic stem cell transplantation (allo-SCT) could improve the outcome of adult Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL], the impact of the donor source, particularly the position of cord blood (CB) transplantation, is still uncertain.

Methods

We retrospectively analyzed 1726 adult Ph(-) ALL patients transplanted at the first time between 1998 and 2009 with myeloablative preparative regimens who were registered in the Japan Society for Hematopoietic Cell Transplantation database. Two hundred and thirty-three received CB transplantation [first complete remission (CR1): 95, subsequent CR: 53, non-CR: 85], 809 received allo-SCT from unrelated donor (URD) (CR1: 434, subsequent CR: 158, non-CR: 217), and 684 received allo-SCT from related donor (RD) (CR1: 388, subsequent CR: 89, non-CR: 207).

Results

Overall survival (OS) in patients after CB transplantation in CR1 was comparable with that after allo-SCT from URD or RD [57% in CB, 64% in URD, and 65% in RD at 4 years, respectively, P = 0.11]. Donor source was not a significant risk factor for OS in multivariate analysis. Although URD was a favorable factor for relapse and an unfavorable factor for non-relapse mortality (NRM), CB was not a significant factor for them [relapse: 22% in CB, 17% in URD, and 24% in RD at 3 years, respectively (P = 0.02); NRM: 27% in CB, 23% in URD, and 13% in RD at 3 years, respectively (P = 0.0001)]. Similarly, OS was not different by donor source in subsequent CR or non-CR [subsequent CR: 48% in CB, 39% in URD and 48% in RD, P = 0.33; non-CR: 18% in CB, 21% in URD, and 15% in RD, P = 0.20 at 4 years, respectively].

Conclusions

Allo-SCT using CB led to similar outcomes as either RD or URD in any disease status. CB transplantation is a good alternative for adult Ph(-) ALL patients without a suitable RD or URD.

Related Topics

    loading  Loading Related Articles