SAFETY AND EFFICACY OF HYPOFRACTIONATED RADIOTHERAPY IN ADJUVANT TREATMENT OF BREAST CANCER

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Abstract

Background

Adjuvant whole breast irradiation reduces the risk of local recurrence; however, it is time consuming to patients. The shorter hypofractionation schedules have been tried mainly in Canada with reasonable outcomes.

Methods

We conducted a retrospective study of the efficacy and safety in patients with N0-1 invasive breast cancer who underwent radiotherapy at our hospital between January 2004 and January 2012. Radiotherapy was either conventional (50 Gy/25 fr)or accelerated hypofractionation (44 Gy/16 fr). Results: There were 257 patients who received conventional and 329 patients who received hypofractionation. The median observation period was 36 weeks. One patient in conventional (0.4%) and three patients in hypofractionation (0.9%) suffered local recurrence. No statistically significant differences were seen between the two groups. There was no increased toxicity in the skin or lung in the hypofractionation group.

Conclusions

These findings suggest that hypofractionated radiotherapy is effective and safe in at least short follow-up. We need longer prospective investigation to confirm these results.

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