For the elimination of cancer-care disparities, it is essential to improve the standard of cancer medical care in the general hospitals, as well as regional core cancer hospitals. Supported by Health Labour Sciences Research Grant, we carried out questionnaire survey for current situation on chemotherapy service of hospitals and extracted the underlying issues. One hundred fifty-three general hospitals, including the regional core cancer hospitals in Tohoku district, were subjected for the questionnaire with six major topics: (i) hospital scale and facilities; (ii) management system of chemotherapy regimens; (iii) operational status of chemotherapy; (iv) status of the clinical-path about chemotherapy; (v) implementation system of clinical trials; and (vi) training of professional medical care stuff. The answers were recovered from 61 hospitals, including 23 regional core cancer hospitals (total recovery rate 39.8%). Registration system of chemotherapy regimen and manuals for adverse events had been developed in almost all regional core cancer hospitals and about half of general hospitals. Providing common chemotherapy regimens and manuals of specialized facilities were general demands from general hospitals. Case conferences are held regularly at more than 90% of regional core cancer hospitals and about 40% of general hospitals. Although 75% of regional core cancer hospitals participated in clinical trials, there is a lack of information of clinical trials and of clinical research coordinators who support medical staffs. To improve these issues, the Tohoku Clinical Oncology Research and Education Group (T-CORE), supported by Health Labour Sciences Research Grant, is addressing the following tasks: publication and disclosure of common chemotherapy regimens, development of the regimen review system, and case conference by a tumor board on the Web.