A 61-year-old woman complaining of anorexia and general fatigue admitted to our hospital for further examination. She was examined and diagnosed as advanced sigmoid colon cancer with multiple metastases of the lung, liver and left hydronephronephrosis. Since curative surgery was deemed not possible, we started chemotherapy with bevacizumab + FOLFOX6 (biweekly drip infusion). After the sixth course, colonoscopy revealed a significant tumor reduction and changes to scar tissues. CT did not revealed complete disappearance but some reduction in metastases of the lung and liver. Sigmoidectomy and lymph node resection (D1) were carried out. We did not disappeared any dissemination and the histological diagnosis revealed complete disappearance of cancer cells in the main tumor. She was discharged 13 days after the surgery following the chemotherapy including bevacizumab and XELOX. The chemotherapy using bevacizumab + FOLFOX6 was a candidate for the standard treatment strategy for advanced colon cancer inoperable. Herein, we report this rare case with a view of the literature.