TREATMENT PATTERNS AND PROGNOSIS OF FIGO STAGE IVB CERVICAL CANCER

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Abstract

Objective

To assess treatment patterns and outcomes in patients with stage IVb cervical cancer.

Methods

A retrospective study of patients with stage IVb cervical cancer at a single institution was carried out.

Results

We identified 47 patients. The median progression-free survival and the overall survival were 5.7 and 11.1 months. Sixteen patients were treated with radiation therapy alone and 31 patients were treated with a combination of radiation therapy and chemotherapy. Of 45 recurrences or progression of disease, 25 patients received best supportive care (BSC) and 20 patients received chemotherapy or radiation therapy or the combination of both modalities. On univariate analysis, non-chemotherapy, BSC after progression of disease, non-chemotherapy or non-radiotherapy after progression of disease were considered poor prognostic factors. On multivariate analysis, non-chemotherapy, non-chemotherapy or non-radiotherapy after progression of disease and non-SCC histology were independent prognostic factors of survival.

Conclusion

Non-chemotherapy, non-chemotherapy or non-radiotherapy after progression of disease, non-SCC histology groups were found to have poor prognosis in patients with stage IVb cervical cancer. Chemotherapy as initial treatment and multimodal treatment after progression of disease may improve the survival of stage IVb cervical cancer.

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