LONG-TERM ADMINISTRATION OF PEMETREXED RAISED TOXICITY OF PERIPHERAL EDEMA TREATED WITH ORAL ANTI-DIURETICS

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Abstract

Background

Pemetrexed has been used as maintenance therapy for non-squamous non-small-cell lung cancer. Treatment period of pemetrexed is relatively longer than that of the other cytotoxic agents. Usually acute adverse events are mild and less frequent; however, it is still unknown if the long-term administration raised toxicities. There are several reports that pemetrexed caused eye lid or peripheral edema, which package insert also described the occurrences were 5 to 20%, 20%, respectively. We investigated if pemetrexed raised occurrence of peripheral edema that was treated with anti-diuretics during the maintenance therapy.

Result

One hundred sixty nine of NSCLC patients were treated with pemetrexed in our institution. Twelve patients were administered of pemetrexed more than 10 times. Anti-diuretics were used in 52 patients (30.2%) and pemetrexed probably induced peripheral edema in 12 patients (7.1%). The rate of administration of anti-diuretics due to the peripheral edema to the patients maintained with pemetrexed in less than 6 times, 6 times and more or 12 times and more was 4.3, 13.2 and 21.7, respectively. We concluded that long-term administration of pemetrexed raised the adverse event of peripheral edema.

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