A Multi-Institutional Comparative Trial of Radiation Therapy Alone and in Combination with 5-fluorouracil for Locally Unresectable Pancreatic Carcinoma

    loading  Checking for direct PDF access through Ovid


One hundred six patients with histologically confirmed pancreatic carcinoma were randomized to one of three radiation treatment programs: 1) radiation therapy alone to 6000 rads; 2) 6000 rads plus 5-FU; or, 3) 4000 rads plus 5-FU. Patient survival was the primary study parameter. Both 4000 rads plus 5-FU (p < .02) and 6000 rads plus 5-FU (p < .01) were associated with a significantly longer patient survival than 6000 rads alone. Respective median survivals were 36 weeks, 40 weeks, and 20 weeks. The survival difference between 4000 rads plus 5-FU and 6000 rads plus 5-FU was not statistically significant at the time point selected.

Related Topics

    loading  Loading Related Articles