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The bactericidal activity of ABT-773 was compared with amoxicillin against 10 clinical isolates of S. pyogenes (six erythromycin susceptible and four erythromycin resistant). The MIC ranges (mg/L) were 0.004–0.25 of ABT-773 and 0.015–0.12 of amoxicillin. At 24 h, ABT-773 concentrations of 2 × MIC and 8 × MIC were bactericidal against three and six organisms, respectively. In comparison, amoxicillin was bactericidal against all 10 organisms at both test concentrations.