Susceptibility of Yersinia pestis to novel and conventional antimicrobial agents

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ObjectivesTo determine the susceptibility of southern African strains of Yersinia pestis to novel as well as conventional antimicrobial agents.Materials and methodsThe MICs of 28 strains of Yersinia pestis from a southern African plague focus were determined by agar dilution.ResultsThe most active agents were cefditoren and the fluoroquinolones, both conventional and novel. The in vitro activity of macrolides was poor against this member of the Enterobacteriaceae.ConclusionFurther investigation of the novel quinolones olamufloxacin (HSR 903) and ABT 492 in animal models of plague would seem to be justified.

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