Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue

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Abstract

For immunocompromised hosts, human cytomegalovirus (CMV) can be a serious problem. For evaluation of antivirals used to treat CMV retinitis, we have used severe combined immunodeficient mice as hosts for human retinal tissue implanted in the eye and subsequently infected with CMV. Treatment with ganciclovir or cidofovir resulted in a significant suppression of CMV replication.

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