Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein-Gated K+ Channel, IKACh

    loading  Checking for direct PDF access through Ovid

Abstract

ABSTRACT:

The muscarinic-gated atrial potassium channel IKACh has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of IKACh have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac IKACh, the mechanism of activation of IKACh by G proteins, and the relevance of IKACh to cardiac physiology.

Related Topics

    loading  Loading Related Articles