In this study, compliance, a mechanical characteristic of the lower leg arteries, was measured noninvasively. Changes in blood volume and pressure were measured using impedance plethysmography and a mercury sphygmomanometer, respectively. Compliance was calculated by dividing the change in blood volume by the change in pulse pressure (systolic-diastolic pressure). Subjects were 24 asymptomatic persons ranging from 30 to 58 years and 14 diabetics ranging from 41 to 59 years. Peak compliance, mean pressure, and systolic pressure were statistically analyzed using a t test between the asymptomatic and diabetic groups. The average peak compliance of the asymptomatic and diabetic groups was measured as 2.79 and 1.82 μL/mmHg/cm, respectively, and these were significantly different (p < 0.01). It was also found that compliance is a better parameter in differentiating vascular disease than the mean or systolic blood pressure.