Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for Conduct Disorder

    loading  Checking for direct PDF access through Ovid

Abstract

Background

Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder.

Objective

To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys.

Design

Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline.

Setting

A community-based sample of twin boys.

Participants

Five hundred fourteen male twins aged 8 to 17 years.

Main Outcome Measure

Conduct disorder.

Results

There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction.

Conclusion

This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.

Related Topics

    loading  Loading Related Articles