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The different distribution of pathologic features in frontotemporal dementia (FTD) and Alzheimer disease (AD) predicts a predominant dysexecutive syndrome in FTD. The Frontal Assessment Battery (FAB) has previously been validated in diseases associated with a frontal lobe dysfunction.To evaluate the sensitivity of the FAB to differentiate FTD and AD.Comparison study.Memory Clinic of the Salpêtrière Hospital, Paris, France.Twenty-six patients with FTD and 64 patients with AD.Comparison of FAB and Mini-Mental State Examination (MMSE) scores between patients with FTD and those with AD.The mean ± SD FAB scores significantly differed between patients with FTD (7.6 ± 4.2) and those with AD (12.6 ± 3.7) (P<.001), but not MMSE scores. The FAB correctly identified 78.9% of the patients. These results were maintained in a subgroup of mildly demented patients (MMSE score, ≥24). In these patients, a cutoff score of 12 on the FAB was optimal to differentiate both disorders (sensitivity, 77%; specificity, 87%).The FAB takes less than 10 minutes to administer and provides an objective measure to distinguish FTD from AD in mildly demented patients.