To determine the efficacy of phenylephrine hydrochloride, a topical vasoconstrictor, in preventing tympanostomy tube obstruction.Design
Prospective, randomized, double-blind, controlled trial of patients undergoing myringotomy with tympanostomy tube insertion.Setting
Academic, tertiary referral medical center.Patients
Two hundred eight patients were enrolled in the study; 157 patients (310 ears) returned for postoperative evaluation.Interventions
Myringotomy with tympanostomy tube insertion was performed in all ears: 139 control ears received ototopical antibiotics and 171 treatment ears received ototopical antibiotics plus topical phenylephrine.Main Outcome Measure
Postoperative tympanostomy tube obstruction.Results
The overall incidence of tympanostomy tube obstruction was 5.2%: 8.6% in the control group and 2.3% in the treatment group. The treatment group demonstrated an odds ratio of 0.25 (95% confidence interval, 0.08-0.78; P=.02).Conclusion
The use of phenylephrine following tympanostomy tube insertion greatly reduces the incidence of tube obstruction.